RAF Typhoon fighter aircraft have conducted a mission with France's air force in a combined operation targeting an hidden munitions depot in Syrian territory employed by the IS group, according to the British defence ministry.
The location, located using reconnaissance, was assessed as containing munitions and bombs, the release indicated, and was positioned in mountainous terrain just north of the ancient city of Palmyra in central Syria.
"The RAF jets employed precision-guided Paveway IV munitions to hit a series of entry passages leading to the facility... preliminary assessments are that the target was engaged successfully," officials stated.
There was no indication of any harm to civilians in the operation on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as the so-called Islamic State - established extremist governance over large swathes of both Syria and Iraq until 2019.
"This action demonstrates our UK leadership, and resolve to work closely with allied nations, to eradicate any resurgence of Daesh and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the minister said.
British military aircraft have carried out surveillance missions over Syrian airspace to "deter any efforts to regroup" of Islamic State after its military defeat at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to every member of British forces involved in this operation for their expertise and their courage," Healey said. "Including them were a great many UK service members deployed over the festive period. This action, to take out terrorist threats who pose a risk to our safety, shows how British military are ready to step up, throughout the year, protecting the UK at home and powerful internationally."
In December, the US military conducted what it called a "large-scale strike" against Islamic State objectives in the country, after an assault claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The U.N. reports Islamic State still has roughly 5-7 thousand militants in both countries.